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Chemotherapy and chemoradiation. Chemotherapy is usually combined with radiation therapy to treat stage 3 esophageal cancer. This is called chemoradiation. The 2 treatments are given during the same time period. Chemoradiation may be offered for stage 3 esophageal cancer: before surgery (neoadjuvant therapy) after surgery (adjuvant therapy). The first thing to know is that stage 3 breast cancer means the cancer has spread beyond the tumor. It has possibly gone to lymph nodes and muscle but hasn't spread to nearby organs. Doctors have previously divided stage 3 into more specific categories (3A, 3B, and 3C) and the cancer subtype, meaning which type of breast cancer you have.

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